The P-Shot, or Priapus Shot, is a non-surgical procedure for men that uses platelet-rich plasma (PRP) derived from the patient's own blood, which is injected into specific areas of the penis to improve erectile function, enhance sensation, potentially increase size and treat various male sexual dysfunction issues. The treatment aims to rejuvenate penile tissue through natural growth factors. How the P-Shot works involves drawing a small amount of blood from the patient; processing the blood in a centrifuge to concentrate platelets; isolating the platelet-rich plasma rich in growth factors; applying numbing cream to the penis; and injecting PRP into specific areas of the penile shaft and head. The injection sites typically include the corpus cavernosum, the erectile tissue chambers; areas along the penile shaft; and sometimes the glans (head) of the penis. What the P-Shot is designed to treat includes erectile dysfunction or difficulty maintaining erections; reduced penile sensation and pleasure; Peyronie's disease causing penile curvature; premature ejaculation in some cases; reduced penile size following prostate surgery; and overall sexual performance enhancement. The biological mechanism involves platelets releasing growth factors including VEGF, PDGF, EGF and TGF-beta; these factors promoting new blood vessel formation (angiogenesis); stimulating tissue regeneration and collagen production; potentially enhancing nerve sensitivity; and improving blood flow to erectile tissue. The P-Shot procedure typically takes 30 to 60 minutes including numbing time; uses a very fine needle for injections; allows immediate return to normal activities; and may cause mild swelling or bruising for a few days. Who might consider the P-Shot includes men with erectile dysfunction seeking non-pharmaceutical treatment; those wanting to enhance sexual performance; men with reduced penile sensation; those with Peyronie's disease; post-prostatectomy patients with erectile changes; and men interested in potential size enhancement. The treatment represents a regenerative medicine approach to male sexual health, using the body's own healing factors to improve function.

The P-Shot may help some men with premature ejaculation, though it is not specifically a cure and evidence for this particular indication is limited. The treatment's potential benefit for premature ejaculation appears to work through improved penile sensitivity control and tissue health rather than directly addressing the ejaculatory reflex. How P-Shot might help premature ejaculation relates to improved tissue health potentially enhancing ejaculatory control; better blood flow possibly affecting sexual stamina; enhanced sensation allowing better awareness and control; tissue regeneration potentially normalizing sensitivity; and some men reporting delayed ejaculation as a benefit. The mechanism is not fully understood but may involve desensitization of hypersensitive areas; improved tissue health affecting nerve function; better blood flow supporting sustained erections; psychological benefits from enhanced confidence; and overall improved sexual function indirectly affecting ejaculatory control. Evidence for P-Shot and premature ejaculation shows limited specific research on this indication; most evidence being anecdotal from patient reports; some practitioners reporting patient success; but lack of rigorous clinical trials; and uncertainty about mechanism of action. What men report about P-Shot for premature ejaculation includes some experiencing improved ejaculatory control; others noticing minimal change; highly variable individual response; and often combined with other treatments. Primary treatments for premature ejaculation that have better evidence include behavioral techniques like start-stop and squeeze methods; topical desensitizing agents; selective serotonin reuptake inhibitors (SSRIs); tramadol in some cases; psychological counseling and sex therapy; and pelvic floor physical therapy. When P-Shot might be considered for premature ejaculation shows it potentially being tried when standard treatments have failed; as part of comprehensive approach to sexual health; when erectile dysfunction coexists with premature ejaculation; and with realistic expectations about uncertain benefit. Realistic expectations about P-Shot for premature ejaculation include understanding it is not specifically approved or primarily indicated for this; evidence is limited compared to erectile dysfunction; results vary significantly between individuals; it may provide some benefit but not cure; and other treatments have stronger evidence. Factors affecting whether P-Shot helps premature ejaculation include the underlying cause of premature ejaculation; whether erectile dysfunction also contributes; individual response to PRP treatment; practitioner experience and technique; and combination with other therapeutic approaches. For men with premature ejaculation, P-Shot might be worth considering as part of comprehensive treatment, but should not be relied upon as primary therapy given the limited specific evidence, and proven treatments should typically be tried first.

The P-Shot may produce modest increases in penile size for some men, with reported gains typically being 1 to 2cm in length and 1 to 2cm in girth, though results vary significantly and dramatic size increases should not be expected. Size enhancement is a secondary benefit rather than the primary purpose of the treatment. How P-Shot might increase size involves growth factors stimulating new tissue formation; increased blood flow potentially expanding erectile tissue capacity; collagen production adding tissue volume; improved erection quality making the penis appear larger; and tissue regeneration potentially enhancing overall penile health. Realistic size expectations show length increases of 0.5 to 2cm being reported by some men; girth increases of 0.5 to 2cm in some cases; improvements being modest not dramatic; significant variation between individuals; and erection quality improvement contributing to apparent size. The size increase mechanism may involve actual tissue growth from regenerative effects; improved blood flow allowing fuller erections; enhanced erection quality maximizing natural size; reduced fibrosis or scar tissue; and optimized penile health allowing best natural dimensions. Evidence for P-Shot size increases includes patient testimonials reporting modest gains; some practitioners documenting measurements; lack of large-scale clinical trials; and uncertainty about permanent versus temporary effects. Factors affecting size increases from P-Shot include your baseline penile dimensions; age and tissue health; individual response to PRP treatment; number of treatments received; erection quality improvement; and realistic measurement and expectations. Whether size increases are permanent shows initial gains possibly from swelling and improved blood flow; longer-term changes potentially from tissue regeneration; maintenance treatments likely needed to sustain benefits; and the permanence of results being unclear. Comparing P-Shot to other size enhancement methods shows it being less dramatic than surgical lengthening or girth enhancement; potentially safer than injectable fillers; non-permanent unlike surgery; and modest compared to marketing claims. What men should understand about P-Shot and size includes the primary benefits being erectile function and sensation; size increase being a potential bonus not guarantee; modest gains being realistic; dramatic transformation being unrealistic; and focusing on function over size being advisable. Realistic expectations about size from P-Shot involve understanding that most benefit comes from improved erection quality appearing larger; actual tissue growth being modest if it occurs; individual results varying dramatically; maintenance being needed to sustain changes; and no guarantee of size increase. For men primarily seeking size enhancement, P-Shot is not the optimal choice, as surgical and other methods produce more significant gains, but for those seeking functional improvement who might gain modest size benefits as well, it may be appropriate with realistic expectations.

The P-Shot works for some men in improving erectile function, sensation and overall sexual satisfaction, with many reporting positive results, though effectiveness varies significantly between individuals and scientific evidence, while growing, is still limited compared to established ED treatments. The treatment shows most promise for specific conditions and appropriate candidates. Evidence supporting P-Shot effectiveness includes patient-reported improvements in erectile function; some clinical studies demonstrating benefit for ED; reports of enhanced sensation and pleasure; improved erection quality and rigidity; and high satisfaction rates in many case series. What the P-Shot may effectively improve shows mild to moderate erectile dysfunction; reduced penile sensation and pleasure; erection quality and firmness; sexual stamina and performance; recovery of erectile function post-prostatectomy; and Peyronie's disease symptoms in some cases. The mechanism supporting effectiveness relates to PRP being proven to promote tissue regeneration in other medical applications; growth factors increasing blood flow to erectile tissue; stimulation of new blood vessel formation; tissue healing and health improvement; and enhanced nerve function and sensitivity. Clinical evidence shows some studies demonstrating 60% to 75% improvement in erectile function scores; improvements in International Index of Erectile Function (IIEF) scores; patient satisfaction rates of 70% to 80% in some series; but lack of large randomized controlled trials; and need for more rigorous long-term studies. Individual variation in response shows some men experiencing dramatic improvement in erectile function; others noticing moderate benefit; some finding minimal or no change; and response relating to ED severity, age and overall health. Factors affecting whether P-Shot works for you include the cause and severity of erectile dysfunction; your age and vascular health; quality and concentration of PRP obtained; injection technique and practitioner expertise; number of treatments received; and realistic expectations about outcomes. Comparing P-Shot to other ED treatments shows PDE5 inhibitors like Viagra working more consistently and immediately; vacuum devices providing reliable mechanical assistance; penile injections offering direct pharmacological effects; and P-Shot potentially providing longer-term tissue improvement. When P-Shot works best shows mild to moderate ED responding better than severe; vascular-related ED potentially benefiting more; men with good overall health having better response; early intervention possibly being more effective; and combination with other treatments potentially enhancing results. Realistic expectations about P-Shot effectiveness include understanding results vary widely between individuals; not all men experience significant benefit; improvement develops gradually over weeks to months; multiple treatments may be needed for optimal results; and the treatment is not FDA approved for erectile dysfunction. For appropriate candidates seeking regenerative approaches to erectile dysfunction, who have realistic expectations and understand the emerging evidence base, P-Shot may provide meaningful improvement, particularly as part of comprehensive sexual health management.

The P-Shot works by injecting concentrated platelet-rich plasma from your own blood into specific areas of the penis, where the growth factors naturally present in platelets stimulate tissue regeneration, improve blood flow, enhance nerve sensitivity and promote overall penile tissue health, resulting in improved erectile function and sensation. The biological process involves drawing approximately 10 to 20ml of blood from your arm; placing the blood in a centrifuge that spins at high speed; separating the platelet-rich plasma from other blood components; concentrating the platelets to 3 to 5 times normal levels; and extracting the PRP for injection. The growth factors in PRP include vascular endothelial growth factor (VEGF) promoting new blood vessel formation; platelet-derived growth factor (PDGF) stimulating tissue repair; epidermal growth factor (EGF) supporting skin and tissue regeneration; transforming growth factor-beta (TGF-β) regulating cell growth; and multiple other factors coordinating healing responses. The injection technique involves applying topical numbing cream to the penis 20 to 30 minutes before treatment; using a very fine needle or cannula for injections; injecting PRP into the corpus cavernosum, the main erectile chambers; distributing injections along the penile shaft; sometimes treating the glans (head) area; and the procedure taking about 30 minutes total. How PRP affects penile tissue shows the growth factors triggering new blood vessel formation (angiogenesis); increased blood flow capacity to erectile tissue; stimulation of fibroblasts producing collagen; tissue repair and regeneration; reduced inflammation and improved tissue health; enhanced nerve sensitivity; and optimization of erectile function. The timeline of effects shows some men noticing initial improvements within 1 to 2 weeks; progressive enhancement over 4 to 12 weeks as tissue regenerates; optimal results typically at 2 to 3 months post-treatment; sustained benefits for 12 to 18 months in responders; and the need for repeat treatments to maintain improvements. The cellular response to P-Shot involves platelets releasing growth factors upon injection; these factors signaling local cells to activate repair; stem cells potentially being recruited to the area; new collagen and blood vessels forming; nerve endings potentially becoming more sensitive; and overall tissue health improving. Why multiple treatments may be beneficial relates to cumulative regenerative effects building over time; progressive tissue improvement with repeated stimulation; some men responding better to series than single treatment; and maintenance treatments sustaining optimal results. The P-Shot differs from other ED treatments because PDE5 inhibitors work pharmacologically to dilate blood vessels temporarily; vacuum devices work mechanically; penile injections cause immediate vasodilation; and P-Shot aims for lasting tissue regeneration. The regenerative approach means working with your body's natural healing; potentially providing sustained rather than temporary improvement; addressing underlying tissue health; and taking time to develop full effects.

P-Shot results typically last 12 to 18 months for men who respond to treatment, though individual duration varies with some experiencing shorter effects and others maintaining benefits for up to 2 years. The temporary nature means maintenance treatments are needed to sustain improvements. The results timeline shows some men noticing initial improvements within 1 to 2 weeks from immediate effects; progressive enhancement over 4 to 12 weeks as tissue regeneration occurs; optimal results typically at 2 to 3 months post-treatment; maintained benefits for 9 to 18 months on average in responders; and gradual diminishing of effects over time. Why P-Shot effects are temporary relates to PRP stimulating tissue regeneration that naturally diminishes; growth factors being eventually absorbed and metabolized; ongoing ageing and tissue changes continuing; natural erectile function decline progressing; and the treatment not providing permanent structural alteration. Duration by benefit type shows erectile function improvements potentially lasting 12 to 18 months; sensation enhancements possibly persisting 9 to 15 months; any size increases being temporary without maintenance; and individual response varying significantly. Factors affecting how long P-Shot lasts include the severity of initial erectile dysfunction; your age and overall vascular health; the quality and concentration of PRP obtained; injection technique and coverage; lifestyle factors including smoking, diabetes control and cardiovascular health; and number of treatments received. Maximizing P-Shot longevity involves maintaining cardiovascular health through exercise and diet; managing diabetes, hypertension and other conditions; avoiding smoking which impairs blood flow; maintaining healthy weight; managing stress and sleep; and scheduling maintenance treatments before effects fully diminish. Maintenance treatment protocols show repeat P-Shot typically recommended every 12 to 18 months; some men needing more frequent maintenance; others maintaining results longer; and individual scheduling based on symptom return. Cumulative effects with repeated treatments show some men experiencing progressively better results with each treatment; improved duration of benefits over time; tissue health potentially improving with consistent regenerative treatment; and long-term benefits from regular maintenance. The concept of tissue regeneration means P-Shot potentially creating lasting improvements in tissue health; blood vessels formed during treatment persisting for months; collagen produced contributing to sustained benefits; but ongoing treatment eventually needed as effects naturally fade. Comparing P-Shot duration to other ED treatments shows PDE5 inhibitors working for hours per dose requiring ongoing use; vacuum devices providing immediate temporary help; penile implants offering permanent solution but being surgical; and P-Shot providing months-long benefit from single treatment. Cost considerations for temporary results include annual or bi-annual treatments representing ongoing investment; cumulative expense over years of use; and weighing temporary benefits against permanent surgical solutions or continuous medication. For most men who respond well to P-Shot, benefits last approximately 12 to 18 months before maintenance treatment is recommended, making it a medium-term rather than permanent solution to erectile dysfunction and sexual performance concerns.

Most men receive an initial P-Shot treatment followed by assessment at 2 to 3 months, with some practitioners recommending a series of 2 to 3 treatments spaced 4 to 8 weeks apart for optimal results, and then maintenance treatments every 12 to 18 months to sustain benefits. The exact protocol varies based on individual response and practitioner approach. Initial treatment protocols show some practitioners recommending single P-Shot with reassessment at 2 to 3 months; others suggesting series of 2 to 3 initial treatments for enhanced effect; spacing between initial treatments of 4 to 8 weeks; and adjustment based on individual response. The rationale for multiple initial treatments involves cumulative regenerative effects potentially being greater; some men responding better to series than single treatment; progressive tissue improvement building over treatments; and optimization of growth factor stimulation. Factors affecting how many P-Shots you need include severity of erectile dysfunction or other concerns; your baseline tissue health and vascular status; response to initial treatment; treatment goals and desired outcomes; practitioner's protocol and experience; and budget considerations. Response assessment after initial treatment shows evaluation at 2 to 3 months allowing full tissue regeneration; measurement of improvement in erectile function and satisfaction; determination of whether additional treatment would be beneficial; and discussion of maintenance protocol. Maintenance P-Shot requirements show most men needing maintenance every 12 to 18 months; some requiring more frequent retreatment; others maintaining benefits longer; and individual scheduling based on symptom return. The cumulative approach shows some practitioners believing initial series provides better foundation; ongoing maintenance sustaining optimal results; progressive tissue health improvement over time; and long-term consistency being important. Comparing single versus multiple P-Shots includes single treatment being less expensive initially but possibly providing less benefit; series potentially optimizing results but increasing cost; and individual response determining optimal approach. Cost considerations for multiple P-Shots show each treatment typically costing £1,000 to £1,500; initial series of 2 to 3 treatments totaling £2,000 to £4,500; annual maintenance adding ongoing expense; and cumulative cost over years being significant. Evidence for optimal treatment number shows limited research on whether series is superior to single treatment; most published studies involving single or double treatments; and protocols varying between practitioners. What most practitioners recommend includes starting with single P-Shot for most men; assessing response at 2 to 3 months; considering second treatment if response is partial; establishing maintenance schedule for responders; and individualizing based on results. Realistic expectations about number of treatments include understanding one P-Shot may be sufficient for some men; others benefiting from initial series; all responders eventually needing maintenance; and no guarantee of specific results regardless of number. For most men, starting with a single P-Shot, assessing results, and then deciding whether additional treatments are warranted provides a reasonable approach, with maintenance every 12 to 18 months for those who respond well.

Before P-Shot treatment, men typically have erectile dysfunction with difficulty achieving or maintaining erections adequate for sexual activity; reduced penile rigidity and firmness; decreased sensation and pleasure during sexual activity; premature loss of erection during intercourse; reduced confidence about sexual performance; anxiety about erectile problems affecting relationships; and in some cases, reduced penile size following prostate surgery or due to ageing. These concerns often significantly impact sexual confidence, intimate relationships and overall quality of life. After P-Shot treatment, following the procedure and allowing time for tissue regeneration and growth factor effects to fully develop (typically assessed at 2 to 3 months post-treatment), men who respond positively report various improvements. Common results among responders include improved ability to achieve and maintain erections; increased erectile rigidity and firmness; enhanced sensation and pleasure during sexual activity; longer-lasting erections with better sustainability; modest increases in penile size reported by some men, typically 0.5 to 2cm in length and/or girth; reduced refractory period between erections; improved sexual confidence and performance; and better overall sexual satisfaction. The results timeline shows that within weeks 1 to 2, some men notice early improvements in sensation or erectile quality; during weeks 2 to 6, progressive enhancement as tissue regeneration begins; during weeks 6 to 12, continued development as new blood vessels form and tissue health improves; at months 2 to 3, optimal results becoming apparent with full regenerative effects; and sustained improvement for 12 to 18 months typically before maintenance is needed. The degree of improvement varies significantly between individuals depending on baseline erectile function and severity of dysfunction; cause of erectile dysfunction, with vascular issues potentially responding well; age and overall cardiovascular health; individual response to PRP treatment; quality of PRP and injection technique; lifestyle factors including smoking, diabetes and vascular health; and realistic expectations about outcomes. Typical improvements among responders show erectile function scores (IIEF) increasing by 30% to 60% in some studies; improvements in rigidity allowing successful intercourse; enhanced spontaneity not requiring pre-planning with medication; reduced reliance on ED medications for some men; and increased sexual confidence and relationship satisfaction. Before and after expectations should be realistic: P-Shot does not work for everyone, with significant individual variation in response; results develop gradually over weeks to months, not immediately; improvement is temporary lasting 12 to 18 months requiring maintenance; not FDA approved with limited large-scale evidence; some men experience minimal or no benefit despite treatment; and outcomes cannot be guaranteed. Factors predicting satisfaction with results include having mild to moderate rather than severe ED; vascular-related ED potentially responding better than neurological; overall good health with controlled risk factors; realistic expectations about gradual improvement; willingness to invest in maintenance treatments; and viewing P-Shot as part of comprehensive sexual health approach. Most men satisfied with P-Shot are responders experiencing meaningful improvement in erectile function; those who appreciate non-pharmaceutical regenerative approach; men wanting to reduce reliance on ED medications; patients with realistic expectations about moderate improvement; and those able to afford ongoing maintenance. Men considering P-Shot should understand the variable effectiveness, emerging evidence base, significant cost, and need for realistic expectations, ideally trying established treatments first and viewing P-Shot as one option in comprehensive erectile health management.