Explore the best clinics for Nucleofill near you – start by picking your city FAQ

Question 1

What is nucleofill

Accepted Answer

Nucleofill is an injectable polynucleotide treatment designed to rejuvenate and improve skin quality from within. It contains highly purified polynucleotides, which are DNA fragments typically derived from salmon or trout sperm, formulated to be biocompatible with human tissue. Unlike traditional dermal fillers that add volume, Nucleofill works as a biostimulator that triggers natural regeneration processes in the skin. The treatment stimulates fibroblast activity, promotes collagen and elastin production, improves tissue hydration and elasticity, supports cellular repair and regeneration, and enhances overall skin health and quality. Nucleofill can be used on various areas including the face, under-eyes, neck, décolletage and hands to address concerns such as fine lines, dull or tired-looking skin, loss of firmness, crepey texture, dark circles, and general signs of ageing. The product comes in different formulations with varying concentrations of polynucleotides for different treatment areas and concerns. Treatment involves small injections delivered into the skin using fine needles or cannulas, typically requiring a series of sessions spaced several weeks apart. Results develop gradually over weeks to months as the regenerative processes are activated, rather than providing instant volume like traditional fillers.

Question 2

How much is Nucleofill?

Accepted Answer

Prices for Nucleofill vary between clinics and depend on a number of factors. In the UK the cost of Nucleofill typically ranges from around £230 to £595. As a polynucleotide skin booster, price depends on the specific product and concentration used, whether you have a single session or a course, the treatment area and goals, and the practitioner’s experience. If you’re searching for how much Nucleofill costs or the price of Nucleofill, expect quotes to be personalised to your treatment plan. You can find the exact, up-to-date price for this treatment in the catalogue.

Question 3

How long does nucleofill last

Accepted Answer

Nucleofill results typically last between 6 to 12 months, with many people experiencing benefits for around 9 months on average, though longevity varies depending on several factors. Because Nucleofill works by stimulating your body's own regenerative processes rather than simply adding temporary volume, the improvements can have relatively lasting effects as the newly produced collagen and improved tissue quality persist even after the polynucleotides themselves have been broken down. The duration of results depends on your age and natural collagen production capacity, with younger patients sometimes experiencing longer-lasting benefits; the treatment area, with some areas maintaining results longer than others; your skin condition and quality at the start of treatment; lifestyle factors including sun protection, skincare routine, smoking and overall health; and the number of sessions completed in the initial treatment course. Most practitioners recommend an initial course of 2 to 4 treatment sessions spaced 2 to 4 weeks apart to build optimal results, followed by maintenance treatments every 6 to 12 months to sustain the improvements. The regenerative effects can continue developing for several months after the treatment course is complete, and some of the tissue remodelling benefits may persist longer term. However, natural ageing processes continue, so periodic maintenance is typically needed to preserve the enhanced skin quality. People who maintain good skincare habits, protect their skin from sun damage and follow healthy lifestyles tend to experience longer-lasting results from Nucleofill treatments.

Question 4

How long does nucleofill take to work

Accepted Answer

Nucleofill works gradually rather than providing instant results, with improvements developing over several weeks to months as the treatment stimulates natural skin regeneration processes. Most people begin to notice subtle changes in skin hydration and texture within 2 to 4 weeks after their first treatment, as the polynucleotides start promoting cellular activity and improving moisture retention. More significant visible improvements in skin quality, firmness, fine lines and overall appearance typically become apparent 4 to 8 weeks after starting treatment, with optimal results usually visible after completing the full course of sessions. The timeline varies between individuals depending on age, starting skin condition, the area being treated, how your body responds to the treatment, and the number of sessions received. Because Nucleofill stimulates your body's own fibroblasts to produce collagen and elastin, these processes take time to develop fully. The benefits continue to improve for up to 3 months after your final treatment session as collagen remodelling and tissue regeneration continue. Results are cumulative, meaning each treatment session builds upon the previous one, with progressive improvement throughout the treatment course. The gradual nature of Nucleofill results is actually an advantage, creating natural-looking improvement that develops progressively rather than sudden, obvious changes. Patience is important, and you should not judge final outcomes until at least 8 to 12 weeks after completing your treatment series. Your practitioner should set realistic expectations about the timeline during your consultation and may schedule follow-up appointments to assess progress and determine if additional sessions are needed.

Question 5

How to inject nucleofill

Accepted Answer

Nucleofill injection should only be performed by qualified, trained medical practitioners with expertise in facial anatomy and injectable techniques. This is not a procedure that should be attempted at home or by unqualified individuals. For medical professionals, the injection technique involves several important considerations. The treatment is typically administered using fine needles or cannulas to deliver small volumes of Nucleofill into the dermis or subcutaneous tissue, depending on the area and concern being addressed. Common injection techniques include multiple small injections (micropapular technique) distributed across the treatment area; linear threading using needles or cannulas; or a combination approach depending on the specific area and concern. For facial treatments, injections are typically placed in a grid pattern across areas like cheeks, forehead or around the eyes. Under-eye treatments require particularly precise technique due to the delicate nature of periorbital tissue. The product should be injected at the appropriate depth, typically mid to deep dermis, and practitioners must understand facial anatomy including the location of blood vessels, nerves and appropriate injection planes. Proper technique requires assessing the patient's individual anatomy and skin condition, determining appropriate injection points and depth, using aseptic technique and proper hygiene protocols, injecting small volumes at multiple points rather than large boluses, and massaging gently if indicated to ensure even distribution. The procedure typically takes 30 to 45 minutes depending on the treatment area. If you are interested in Nucleofill treatment, book an appointment with a qualified aesthetic practitioner who has proper training in polynucleotide treatments. They will assess your suitability, create an appropriate treatment plan and perform the injections safely and effectively.

Question 6

Is nucleofill a filler

Accepted Answer

No, Nucleofill is not a traditional dermal filler, though both are injectable treatments. The distinction is important for understanding what Nucleofill does and what results to expect. Traditional dermal fillers, usually made from hyaluronic acid or other volumising substances, work by physically adding volume to the injected area, creating immediate filling, plumping or contouring effects that are visible right away. Nucleofill, by contrast, is a biostimulator or skin booster that works by stimulating your body's natural regeneration processes rather than adding volume. It contains polynucleotides that trigger biological responses including collagen production, tissue repair and improved hydration, without providing significant volumising effect. While fillers change your facial structure or fill specific lines and hollows, Nucleofill improves overall skin quality, texture, hydration and health without altering contours. The results from fillers are immediate, while Nucleofill results develop gradually over weeks to months. Fillers are used for specific structural concerns like nasolabial folds, lips or cheek volume, whereas Nucleofill addresses skin quality issues like fine lines, texture, dullness and early signs of ageing. You can think of fillers as providing the physical structure, while Nucleofill provides biological rejuvenation. In some comprehensive treatment plans, practitioners may combine both approaches, using fillers for volume and contour alongside Nucleofill for overall skin quality improvement. If you are seeking immediate volume or structural changes, traditional fillers would be more appropriate. If you want to improve skin health, texture and quality with natural-looking gradual results, Nucleofill may be suitable. A consultation with an experienced practitioner can help determine which approach or combination best addresses your specific concerns.

Question 7

Is nucleofill a polynucleotide

Accepted Answer

Yes, Nucleofill is a polynucleotide treatment. It belongs to the category of injectable polynucleotide products used in aesthetic medicine for skin rejuvenation and regeneration. Polynucleotides are chains of nucleotides, which are the building blocks of DNA and RNA. In aesthetic treatments like Nucleofill, these polynucleotides are typically derived from salmon or trout DNA, highly purified and formulated to be biocompatible with human tissue. Nucleofill is one of several polynucleotide brands available, alongside others like Plinest, Ameela, Jalupro HMW and various other formulations. While all are polynucleotide treatments working on similar principles, different products may vary in their specific formulation, concentration of polynucleotides, molecular weight, additional ingredients, and recommended treatment protocols. The polynucleotides in Nucleofill work by stimulating fibroblast activity and cellular regeneration, promoting collagen and elastin synthesis, improving tissue hydration and repair, supporting skin healing processes, and enhancing overall tissue quality. This makes polynucleotide treatments like Nucleofill particularly effective for skin rejuvenation, improving texture and tone, addressing early signs of ageing, and enhancing skin health. Nucleofill is sometimes described as a 'DNA injection' or 'salmon DNA treatment' in non-technical terms, though these are oversimplifications. The product has been processed and purified specifically for aesthetic use. If you are interested in polynucleotide treatments, your practitioner may offer Nucleofill or alternative polynucleotide products depending on their assessment of your specific needs and their available products and training.

Question 8

Does nucleofill work

Accepted Answer

Nucleofill can be effective for improving skin quality and addressing certain aesthetic concerns when used appropriately on suitable candidates. Clinical evidence and patient experiences suggest that polynucleotide treatments like Nucleofill can produce noticeable improvements in skin hydration, texture, firmness and overall quality. The treatment has shown positive results for addressing concerns such as fine lines and wrinkles, dull or tired-looking skin, loss of elasticity and firmness, crepey or rough texture, dark circles and under-eye concerns, and early signs of ageing. However, effectiveness varies significantly depending on several factors including the severity and type of concerns being addressed, with skin quality issues responding better than structural problems; realistic expectations about gradual, natural-looking improvement rather than dramatic transformation; your age and natural collagen production capacity; skin condition and quality at the start of treatment; completing the recommended treatment course, typically 2 to 4 sessions; and the skill and experience of your practitioner. Nucleofill works best for people seeking improvement in overall skin health and quality rather than volume replacement or dramatic structural changes. It is not effective for significant volume loss, deep wrinkles, severe sagging or concerns that would require volumising fillers or surgical intervention. The treatment provides subtle to moderate improvements that develop gradually, making it suitable for people who want natural-looking rejuvenation. Because polynucleotides work by stimulating natural regeneration processes, results can vary between individuals based on their body's response. Some people see quite noticeable improvement in skin radiance, texture and firmness, while others may experience more modest changes. The treatment is often combined with other aesthetic procedures like fillers, toxins or skin treatments for comprehensive facial rejuvenation. A thorough consultation with an experienced practitioner can help determine whether Nucleofill is likely to be effective for your specific concerns and whether it is the most appropriate treatment option for your goals.

Question 9

Is nucleofill safe

Accepted Answer

Nucleofill is generally considered safe when administered by properly qualified and trained practitioners in appropriate clinical settings, with a good safety profile reported in clinical use. The polynucleotides in Nucleofill are biocompatible and have been used in medical applications for tissue repair and regeneration. Because the product works by stimulating natural processes rather than introducing foreign permanent substances, the risk profile is generally favourable. Common side effects are typically mild and temporary, including redness, swelling or slight bruising at injection sites, which usually resolve within a few days; tenderness or sensitivity in treated areas; small bumps or lumps that typically settle as the product integrates; and temporary firmness at injection points. Rare but potential complications can include infection if proper sterile technique is not followed or aftercare instructions are not adhered to; allergic reactions, though uncommon due to the biocompatible nature of polynucleotides; prolonged swelling or inflammation in sensitive individuals; asymmetry or uneven results; vascular complications if injected incorrectly, though this risk is lower than with volumising fillers; and unsatisfactory results or lack of expected improvement. Safety depends heavily on proper patient selection through thorough consultation and medical history assessment, with treatment not suitable for people with active infections, certain autoimmune conditions, pregnancy or breastfeeding, or specific allergies; using genuine, properly stored products from reputable manufacturers; treatment by qualified medical practitioners with appropriate training in injectable techniques and facial anatomy; following proper injection protocols and aseptic technique; adhering to post-treatment care instructions; and realistic expectations about outcomes. The long-term safety profile of polynucleotide treatments is still being studied, as these are relatively newer aesthetic treatments compared to traditional fillers. Always choose a qualified medical practitioner who conducts thorough consultations, uses genuine products, follows proper protocols and provides comprehensive aftercare. Disclose your full medical history, medications and any concerns during consultation to ensure the treatment is appropriate and safe for you.

Question 10

Nucleofill before and after

Accepted Answer

Before Nucleofill treatment, people typically have concerns such as dull, tired or lacklustre skin lacking vitality and radiance; fine lines and subtle wrinkles; loss of skin firmness and elasticity; rough, uneven or crepey skin texture; under-eye concerns including dark circles, hollowness or tired appearance; dehydrated or dry-looking skin; early signs of ageing without significant volume loss; or simply wanting to improve overall skin health and quality. The skin may appear aged, fatigued or showing the cumulative effects of sun damage, stress and natural ageing. After completing a course of Nucleofill treatments, typically 2 to 4 sessions over 6 to 12 weeks, and allowing time for the regenerative processes to develop (usually assessed 8 to 12 weeks after the final session), most people experience improvements in overall skin quality and appearance. Common reported benefits include more hydrated, plump and healthy-looking skin; improved skin texture with smoother, more refined appearance; enhanced radiance and glow; better skin firmness and elasticity; softening of fine lines; reduction in the appearance of dark circles or under-eye concerns; more even skin tone; and overall fresher, more youthful-looking skin. The degree of improvement varies considerably depending on starting skin condition and age, with better results typically in people with mild to moderate concerns; the number of sessions completed and adherence to the recommended protocol; individual response to treatment and natural collagen production capacity; the specific areas treated; and realistic expectations about subtle to moderate rather than dramatic changes. Results from Nucleofill are generally natural-looking and progressive, with the skin appearing like a healthier, more rejuvenated version of itself rather than dramatically altered. The improvements are often described as subtle but meaningful, with people noticing they look more rested, refreshed and healthy. Immediately after each treatment session, there will be mild redness, possible swelling and small injection marks that typically resolve within a few days. The actual improvements in skin quality develop gradually over the following weeks as the polynucleotides stimulate collagen production and tissue regeneration. Final results are best assessed 2 to 3 months after completing the treatment course. Your practitioner should provide realistic before and after photos from their own work showing typical results after the full treatment course and regeneration period. Because Nucleofill provides gradual, natural improvement rather than dramatic transformation, changes may be more apparent in person than in photographs. Many people report that others notice they look healthier and more rested without being able to identify exactly what has changed, which is often the desired outcome for natural-looking rejuvenation. Results typically last 6 to 12 months, with maintenance treatments recommended to sustain the improved skin quality over time.

Treatments

Top Clinics

NOT SURE WHAT’S RIGHT FOR YOU?

South of England

North of England

Midlands

Northern Ireland & East

Scotland & Wales

Find Clinics Near You

Injectables

IV therapy / vitamin injections

Skin rejuvenation

Body contouring

Hair removal

Hair restoration

Dermatology

Medical weight management

Sexual wellness

Consultations

Injectables

IV therapy / vitamin injections

Hair removal

Hair restoration

Skin rejuvenation

Dermatology

Medical weight management

Body contouring

Sexual wellness

Consultations

Injectables

IV therapy / vitamin injections

Medical weight management

Skin rejuvenation

Sexual wellness

Body contouring

Consultations

Hair removal

Hair restoration

Dermatology

Nucleofill near you

Juicy Face

NucleoFILL Treatment

Bijoux Medispa

Nucleotides, Dermalux Triwave LED£400

Dr Mihaela Clinic

Polynucleotides Nucleofill 3 Sessions

Polynucleotides Nucleofill

InnoDerm Clinic

Nucleofill Soft Plus (Eyes) (Course of 1)

Nucleofill Soft Plus (Eyes) (Course of 1)

Nucleofill Medium / Strong (Face) (Course of 1)

The Lovely Clinic

Nucleofill™ double treatment

Nucleofill™

One Skin Clinic

Nucleofill face

Nucleofill under eyes

AL Aesthetics

NCTF® Skin Revitalisation - Course of 4 (Eyes)

NCTF® Skin Revitalisation - Half Face

Astrum Medical

Nucleofill Polynucleotides for Neck

Twoth Dental + Facial Aesthetics St Johns Wood

Nucleofill - per syringe

Facial Aesthetics in The City

Nucleadyn 1 Treatment

Open Dental Care

Nucleofill Soft Eyes

Polski Dentysta Londyn - Atrium Clinic Acton

Nucleofill £250

Monet Aesthetics

NUCLEOFILL x2 areas

Nucleofill per area

ArtMedica - Centrum Medyczne Londyn – Acton

Zagęszczanie, ujędrnianie skóry (Nucleofill)

Thames Dental and Skin

Nucleofil Eyes Treatment

ME

Polynucleotides Nucleofil Soft Eyes Treatment

Polynucleotides Nucleofil