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Polynucleotides

£200–£450

Stimulate your skin's natural repair process with an injectable treatment that improves texture, elasticity, and hydration from within.

Duration 30–45 min
Downtime 0–12 hrs
Results in 2–4 weeks
Longevity 6–9 months
(after full course)
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Injectable · Regenerative · Skin Quality · No Downtime
About

What Are Polynucleotides?

Polynucleotides are a regenerative injectable treatment that improves skin quality by stimulating the body's own healing response. They are made from purified fragments of DNA — often sourced from salmon — and help boost collagen, elastin, and hydration in the skin. Unlike fillers or anti-wrinkle injections, polynucleotides don't change the shape or movement of your face. Instead, they work on skin texture, tone, and resilience from the inside out.

Common treatment areas:

  • Under eyes (for dark circles and fine lines)
  • Cheeks
  • Neck
  • Décolletage
  • Acne-scarred or textured skin
  • Any area showing early signs of ageing or dullness
Process

What to Expect

A practitioner will inject small amounts of polynucleotides into the superficial layers of the skin. This stimulates tissue regeneration, improves hydration, and enhances the skin's ability to repair itself. Results develop gradually over a course of treatments, with visible improvements in texture and glow.

Treatment time

30–45 minutes

Pain level

Mild — often described as small stings or pressure

Downtime

0–12 hours
(some swelling or redness may occur)

When results appear

2–4 weeks after first treatment

Full results

After completing a course of 2–3 sessions

Longevity

Around 6–9 months

Look and feel

Healthier, firmer, smoother skin with
improved elasticity and radiance
fit

Is It Right for Me?

This treatment may be suitable if

  • You want to improve skin texture, tone, or hydration
  • You're noticing early signs of ageing or dullness
  • You're looking for a natural-looking result with no changes to facial structure
  • You want a regenerative treatment to support skin health over time
care

Pre-Care & Aftercare

Before your appointment

  • Avoid alcohol, aspirin, and ibuprofen for 24–48 hours
  • Pause retinoids and exfoliating products for 3–5 days
  • Stay well hydrated

After your appointment

  • Avoid touching or rubbing the treated area
  • Avoid alcohol, exercise, or saunas for 24 hours
  • Wait 48 hours before applying active skincare products
  • Avoid other facial treatments for at least 1 week
reviews

What People Are Saying

Sophie, London-0-starSophie, London-1-starSophie, London-2-starSophie, London-3-starSophie, London-4-star

My skin looked fresher and smoother after just two sessions. It wasn't instant, but the change was real.

Sophie, London

Alex, Brighton-0-starAlex, Brighton-1-starAlex, Brighton-2-starAlex, Brighton-3-starAlex, Brighton-4-star

I didn't want anything too drastic — just better skin. This made my under-eye area look less tired and more hydrated.

Alex, Brighton

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faqs

Yes. Polynucleotides are well-tolerated and widely used in regenerative medicine. Side effects are usually mild, such as redness, swelling, or small injection bumps that settle quickly.

Fillers add volume or definition. Polynucleotides improve skin quality by triggering regeneration. They don't change facial structure — they focus on hydration, elasticity, and texture.

Most people need 2–3 treatments spaced 2–4 weeks apart for best results. Your practitioner will recommend a plan based on your skin and goals.

It's usually well tolerated. You may feel a bit of pressure or mild stinging, but numbing cream is often used to make it more comfortable.

Yes. It's often combined with other skin treatments like microneedling or LED therapy. Your practitioner will advise on the best timing.

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