polynucleotides
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Polynucleotides

Book from 261+ сlinics near you
Dr L’Art
star
5.0
(111 reviews)
£££
Verified Partner
Verified Partner
WC1A 1BA, 29-31 New Oxford Street, LondonWC1A 1BA, 29-31 New Oxford Street, London
Get directionsGet directions to Dr L’Art
It was a really great experience. I've been troubled by sensitive skin for a long time. The experience with the photon has improved my skin. The service was very professional. I will come again!😊

It was a really great experience. I've been troubled by sensitive skin for a long time. The experience with the photon has improved my skin. The service was very professional. I will come again!😊

UKALM Health - Wellness, Longevity & Aesthetics
star
5.0
(44 reviews)
£££
Verified Partner
Verified Partner
W1G 9PF, 10 Harley St, LondonW1G 9PF, 10 Harley St, London
Get directionsGet directions to UKALM Health - Wellness, Longevity & Aesthetics
Dr. Armani and his partner were very thorough and listened to every concern when taking my health history. I actually felt listened to (unlike the NHS GP), and that he genuinely cared. His partner was able to assist in checking my hormone levels and give me the hormone replacement therapy that I had previously received in the US, which was a relief after going back-and-forth with the NHS who told me it “wasn’t a thing here”. There was obviously a lot of time and energy put into my care plan (34 pages!), and the communication has been great! If you’re not getting the care you need, and GP’s are brushing off your concerns, I highly recommend!

Dr. Armani and his partner were very thorough and listened to every concern when taking my health history. I actually felt listened to (unlike the NHS GP), and that he genuinely cared. His partner was able to assist in checking my hormone levels and give me the hormone replacement therapy that I had previously received in the US, which was a relief after going back-and-forth with the NHS who told me it “wasn’t a thing here”. There was obviously a lot of time and energy put into my care plan (34 pages!), and the communication has been great! If you’re not getting the care you need, and GP’s are brushing off your concerns, I highly recommend!

nüseoul
star
5.0
(40 reviews)
£££
Verified Partner
Verified Partner
W1H 1QU, 90 York Street, LondonW1H 1QU, 90 York Street, London
Get directionsGet directions to nüseoul
I came across Nûseoul after some research on micro needling. I liked that it was a doctor-led clinic and the team was East Asian using Korean products.  I felt assured by Dr Jenny's clear, informative approach. It was by far the most pleasant microneedling session I have had! She recommended polynucleotides to address my other aging skin concerns so I followed up two weeks later with Dr Byron. After a week, my skin started to feel hydrated and plump from the inside. I am very happy with the results from both treatments. The team is professional, friendly and the communication has been consistent for the after-care which I really appreciated.

I came across Nûseoul after some research on micro needling. I liked that it was a doctor-led clinic and the team was East Asian using Korean products. I felt assured by Dr Jenny's clear, informative approach. It was by far the most pleasant microneedling session I have had! She recommended polynucleotides to address my other aging skin concerns so I followed up two weeks later with Dr Byron. After a week, my skin started to feel hydrated and plump from the inside. I am very happy with the results from both treatments. The team is professional, friendly and the communication has been consistent for the after-care which I really appreciated.

Banhidy Clinic
star
5.0
(23 reviews)
£££
Verified Partner
Verified Partner
SW1Y 5EA, 120 Pall Mall, LondonSW1Y 5EA, 120 Pall Mall, London
Get directionsGet directions to Banhidy Clinic
Such a lovely experience from start to finish. A clean and calm environment in the clinic, everything was explained clearly to me. The 2 brothers that run it are really lovely and made me feel at ease. As 2 trained doctors, I really felt confident and comfortable they knew their stuff!!! I got Polynucleotides and I felt so at ease. The before and after care has been amazing. Can’t wait to go again

Such a lovely experience from start to finish. A clean and calm environment in the clinic, everything was explained clearly to me. The 2 brothers that run it are really lovely and made me feel at ease. As 2 trained doctors, I really felt confident and comfortable they knew their stuff!!! I got Polynucleotides and I felt so at ease. The before and after care has been amazing. Can’t wait to go again

DRV Clinic
star
4.9
(169 reviews)
£££
Verified Partner
Verified Partner
W1U 6UD, 136 Baker Street, LondonW1U 6UD, 136 Baker Street, London
Get directionsGet directions to DRV Clinic
Amazing staff , makes you feel comfortable ,listen your needs resulting desired procedure.
For sure I will be back again!

Amazing staff , makes you feel comfortable ,listen your needs resulting desired procedure. For sure I will be back again!

SAS Aesthetics
star
4.9
(57 reviews)
£££
Verified Partner
Verified Partner
W1G 8BY, 45 Weymouth Street, LondonW1G 8BY, 45 Weymouth Street, London
Get directionsGet directions to SAS Aesthetics
My experience at SAS clinic was great
The stuff was very welcoming and doctor Mahsa was very exhaustive in explaining me the treatment and made me feel very comfortable
The treatment it self was pain free and it’s healing fast .. also post treatment pain was minimal and results are looking really good,
Very happy.

My experience at SAS clinic was great The stuff was very welcoming and doctor Mahsa was very exhaustive in explaining me the treatment and made me feel very comfortable The treatment it self was pain free and it’s healing fast .. also post treatment pain was minimal and results are looking really good, Very happy.

Harley Street Dermal
star
5.0
(1081 reviews)
£££
W1G 9PF, 10 Harley Street, LondonW1G 9PF, 10 Harley Street, London
Get directionsGet directions to Harley Street Dermal
The team here at Harley Street are welcoming, approachable and answered all my queries without any issues. My treatment was smooth and Dr Ria was understanding, professional and patient. Pleased with everything they have offered.

The team here at Harley Street are welcoming, approachable and answered all my queries without any issues. My treatment was smooth and Dr Ria was understanding, professional and patient. Pleased with everything they have offered.

JB Aesthetics
star
5.0
(286 reviews)
£££
W1H 6HJ, Unit 1 Orchard Street, LondonW1H 6HJ, Unit 1 Orchard Street, London
Get directionsGet directions to JB Aesthetics
Dr. Sarah is the best, so caring and kind and an expert at what she does! Masseter botox has literally changed my life, it has helped all my jaw/ tension issues. Can't recommend Dr. Sarah enough!

Dr. Sarah is the best, so caring and kind and an expert at what she does! Masseter botox has literally changed my life, it has helped all my jaw/ tension issues. Can't recommend Dr. Sarah enough!

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star
5.0
(225 reviews)
£££
WC2H 0DT, Charing Cross Road, LondonWC2H 0DT, Charing Cross Road, London
Get directionsGet directions to Anti Wrinkle Clinic - Dr Yiannis Valilas
I needed a treatment for my overgrown masseter, and I couldn’t have chosen a better clinic. Dr. Yiannis is highly skilled and knowledgeable, and I felt I could completely trust him. The results are excellent. He was very careful with the dosage and explained everything in detail.
We also discussed some future treatments to help me reach my skin goals, and he fully respected my decision to avoid fillers, etc. Instead, he suggested treatments that naturally stimulate skin renewal.
The clinic is conveniently located right next to Tottenham Court Road station, and communication was super easy via WhatsApp with his very kind assistant. I’ll be coming back! :)

I needed a treatment for my overgrown masseter, and I couldn’t have chosen a better clinic. Dr. Yiannis is highly skilled and knowledgeable, and I felt I could completely trust him. The results are excellent. He was very careful with the dosage and explained everything in detail. We also discussed some future treatments to help me reach my skin goals, and he fully respected my decision to avoid fillers, etc. Instead, he suggested treatments that naturally stimulate skin renewal. The clinic is conveniently located right next to Tottenham Court Road station, and communication was super easy via WhatsApp with his very kind assistant. I’ll be coming back! :)

The Aesthetics Doctor
star
5.0
(153 reviews)
£££
W1K 5NX, 71 Duke Street, LondonW1K 5NX, 71 Duke Street, London
Get directionsGet directions to The Aesthetics Doctor
I’ve been seeing Dr Ahmed for over a year now for a range of different treatments. Laser, filler and botox mainly, all of which I’m SO happy with. I trust him entirely to be honest, professional and informative with everything that I need making sure he always gets the best results which are look amazing but always subtle and natural at the same time!

I’ve been seeing Dr Ahmed for over a year now for a range of different treatments. Laser, filler and botox mainly, all of which I’m SO happy with. I trust him entirely to be honest, professional and informative with everything that I need making sure he always gets the best results which are look amazing but always subtle and natural at the same time!

OSO Aesthetics & IV Drip Clinic
star
5.0
(145 reviews)
£££
EC1N 7UU, 1-5 Portpool Lane, LondonEC1N 7UU, 1-5 Portpool Lane, London
Get directionsGet directions to OSO Aesthetics & IV Drip Clinic
I had a Rejuran treatment and IV Drip here and was really impressed with the experience. The doctor was very attentive and took the time to understand my concerns. I really appreciated how well they understood Asian beauty aesthetics. Highly recommend!

I had a Rejuran treatment and IV Drip here and was really impressed with the experience. The doctor was very attentive and took the time to understand my concerns. I really appreciated how well they understood Asian beauty aesthetics. Highly recommend!

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star
5.0
(144 reviews)
£££
SW8 2FQ, 19 Cellini Street, LondonSW8 2FQ, 19 Cellini Street, London
Get directionsGet directions to Our Skin Clinic
I’ve been coming to this place for years now and they transformed my skin completely!
From facials, chemical peels to injectables.
The entire team is amazing, extremely knowledgeable and welcoming.

The location of Nine Elms is very convenient for me and easy to get to.

Couldn’t recommend enough, thank you all!!!

I’ve been coming to this place for years now and they transformed my skin completely! From facials, chemical peels to injectables. The entire team is amazing, extremely knowledgeable and welcoming. The location of Nine Elms is very convenient for me and easy to get to. Couldn’t recommend enough, thank you all!!!

Dr Ifrah Aesthetic Clinic
star
5.0
(115 reviews)
£££
W1G 9QN, 23 Harley Street, LondonW1G 9QN, 23 Harley Street, London
Get directionsGet directions to Dr Ifrah Aesthetic Clinic
Dr Ifrah is a friendly and caring doctor who takes time to listen to you. She puts you at ease and talks you through the process making sure you fully understand everything.

The fact that she is a qualified doctor makes you feel you are in safe hands.

I initially went for botox whilst i was there I spoke about my concerns, bags under eyes and loss of texture in my face.
She recommended I try the polynucleotide treatment, the results have been amazing especially under my eye area.  Thank you so much I will highly recommend you.

Dr Ifrah is a friendly and caring doctor who takes time to listen to you. She puts you at ease and talks you through the process making sure you fully understand everything. The fact that she is a qualified doctor makes you feel you are in safe hands. I initially went for botox whilst i was there I spoke about my concerns, bags under eyes and loss of texture in my face. She recommended I try the polynucleotide treatment, the results have been amazing especially under my eye area. Thank you so much I will highly recommend you.

Avika Aesthetics (W1G 6BP)
star
5.0
(80 reviews)
£££
W1G 6BP, 5 Upper Wimpole Street, LondonW1G 6BP, 5 Upper Wimpole Street, London
Get directionsGet directions to Avika Aesthetics (W1G 6BP)
My experience with Dr. Avika has been excellent. The first half of my appointment was talking with her about I was hoping to achieve and then she gave her opinions and suggestions. She took so much time to understand what I wanted and really made sure my results were natural. Unlike other doctors, I felt like Dr. Avika really listened to me and did not rush at all. Her work is amazing and will be going back!

My experience with Dr. Avika has been excellent. The first half of my appointment was talking with her about I was hoping to achieve and then she gave her opinions and suggestions. She took so much time to understand what I wanted and really made sure my results were natural. Unlike other doctors, I felt like Dr. Avika really listened to me and did not rush at all. Her work is amazing and will be going back!

Geometry Clinic
star
5.0
(78 reviews)
£££
W1G 6AR, 115a Harley Street, LondonW1G 6AR, 115a Harley Street, London
Get directionsGet directions to Geometry Clinic
I cannot recommend Dr. Lana and the Geometry Clinic enough! She is an expert at all things aesthetic medicine, and the only person that I trust with my face (have been seeing her for years). She approaches every appointment with genuine care, wanting to understand your desired results so she can help you build confidence on the inside too. She is highly skilled, and knowledgeable, so she’s able to explain all the science behind the treatments. You are the best Lana!

I cannot recommend Dr. Lana and the Geometry Clinic enough! She is an expert at all things aesthetic medicine, and the only person that I trust with my face (have been seeing her for years). She approaches every appointment with genuine care, wanting to understand your desired results so she can help you build confidence on the inside too. She is highly skilled, and knowledgeable, so she’s able to explain all the science behind the treatments. You are the best Lana!

Dermatology Skincare Centre
star
5.0
(75 reviews)
£££
W1G 9PB, 4 Harley Street, LondonW1G 9PB, 4 Harley Street, London
Get directionsGet directions to Dermatology Skincare Centre
I had such a great experience during my skin consultation with Sam. She was not only knowledgeable but also incredibly thorough. She took the time to explain everything clearly and offered fantastic, tailored advice on products and treatments that would benefit my skin. Would definitely recommend for anyone who's lost with where to start on their skincare journey!

I had such a great experience during my skin consultation with Sam. She was not only knowledgeable but also incredibly thorough. She took the time to explain everything clearly and offered fantastic, tailored advice on products and treatments that would benefit my skin. Would definitely recommend for anyone who's lost with where to start on their skincare journey!

Perfectus Derma Aesthetics
star
5.0
(71 reviews)
£££
WC2H 0DT, Charing Cross Road, LondonWC2H 0DT, Charing Cross Road, London
Get directionsGet directions to Perfectus Derma Aesthetics
10/10 experience. The clinic was lovely and very easy to find. Arek, Terry and Olivia were so attentive and knowledgeable, and I can already see such a difference in my under eyes after my first session of polynucleotides. Thank you so much!😊

10/10 experience. The clinic was lovely and very easy to find. Arek, Terry and Olivia were so attentive and knowledgeable, and I can already see such a difference in my under eyes after my first session of polynucleotides. Thank you so much!😊

Skin Doctor Clinics
star
5.0
(62 reviews)
£££
W1W 6XF, 91a New Cavendish Street, LondonW1W 6XF, 91a New Cavendish Street, London
Get directionsGet directions to Skin Doctor Clinics
Maddie is wonderful very knowledgeable and she took care of me so well. I did a course of 3 micro needling and she was amazing at making sure my journey was seamless. My skin looks amazing and I’ll be back for sure!

Maddie is wonderful very knowledgeable and she took care of me so well. I did a course of 3 micro needling and she was amazing at making sure my journey was seamless. My skin looks amazing and I’ll be back for sure!

Allure Skin Aesthetics
star
5.0
(55 reviews)
£££
W1T 4PS, 85 Charlotte Street, LondonW1T 4PS, 85 Charlotte Street, London
Get directionsGet directions to Allure Skin Aesthetics
I feel incredibly fortunate to have found Silma since moving to London. Her exceptional attention to detail, extensive experience, and deep clinical knowledge immediately put you at ease. Silma’s skill and artistry consistently deliver natural, beautiful results, and her professionalism makes every appointment a positive experience. I would highly recommend her to anyone seeking a trusted and talented cosmetic injector.

I feel incredibly fortunate to have found Silma since moving to London. Her exceptional attention to detail, extensive experience, and deep clinical knowledge immediately put you at ease. Silma’s skill and artistry consistently deliver natural, beautiful results, and her professionalism makes every appointment a positive experience. I would highly recommend her to anyone seeking a trusted and talented cosmetic injector.

Emma Wedgwood Aesthetics
star
5.0
(44 reviews)
£££
W1K 2QB, 48 South Audley Street, LondonW1K 2QB, 48 South Audley Street, London
Get directionsGet directions to Emma Wedgwood Aesthetics
I have had treatments with Emma in Harley st and her Kingston clinic.
Emma is very knowledgeable and highly skilled at what she does and put me at ease straightaway with her warm personality and infectious laugh. I knew I was in safe hands.
I have had two Polynucleotide treatments around the eyes so far and the difference is amazing, so much fresher. My friends have started commenting how fresh I look, I would 100 % recommend Emma. Looking forward to my next treatment 😊

I have had treatments with Emma in Harley st and her Kingston clinic. Emma is very knowledgeable and highly skilled at what she does and put me at ease straightaway with her warm personality and infectious laugh. I knew I was in safe hands. I have had two Polynucleotide treatments around the eyes so far and the difference is amazing, so much fresher. My friends have started commenting how fresh I look, I would 100 % recommend Emma. Looking forward to my next treatment 😊

New to Polynucleotides?

New to Polynucleotides?

Learn what this treatment is and how it works.

Learn more

reviews

Zors S-0-starZors S-1-starZors S-2-starZors S-3-starZors S-4-star

I have been to see Dr Rebecca since last September, and I really can’t praise her enough!! She has a lovely calm demeanor, and she always makes time to answer any questions, so you are reassured and comfortable. I highly recommend Dr Rebecca. She is friendly, lovely and very professional. Her treatment room is a tranquil area, which is beautifully kept. The treatments are excellent, and any bruising or discomfort are usually minimal. I love the Polynucleotide treatments, and I look forward to seeing Rebecca for a long time to come! As well as trying out other treatments. Thank you Dr Rebecca you are amazing!! Until the next time. 🙂

Zors S

Zors S

June 14
Charlotte Robson-0-starCharlotte Robson-1-starCharlotte Robson-2-starCharlotte Robson-3-starCharlotte Robson-4-star

Had polynucleotides with Hannah today after a great consultation with her recently. I feel like I’m in the safest hands! She was so excited to see the results it just made me feel absolutely buzzing. She explained what she was doing and why and how at every stage and I’m excited to partner with her more for my skin in future!

Charlotte Robson

Charlotte Robson

November 8
Megan Lane-0-starMegan Lane-1-starMegan Lane-2-starMegan Lane-3-starMegan Lane-4-star

I saw Farhana for polynucleotide treatments after being interested for a long time. I was nervous about the treatment as it was my first time, but Farhana was so friendly, gentle and reassuring. The clinic itself is lovely and welcoming and the treatment went great. Farhana went above and beyond - I had just arrived in Harrogate after a stressful day of travel from the US including lost luggage, and she hooked me up with some samples of cleansers and lotions as well as advice about where I could purchase some other essentials. I only wish I lived in the area so I could frequent this business more often. Thank you Farhana and Blush!

Megan Lane

Megan Lane

June 14
Queenie Cheung-0-starQueenie Cheung-1-starQueenie Cheung-2-starQueenie Cheung-3-starQueenie Cheung-4-star

I had a Rejuran treatment and IV Drip here and was really impressed with the experience. The doctor was very attentive and took the time to understand my concerns. I really appreciated how well they understood Asian beauty aesthetics. Highly recommend!

Queenie Cheung

Queenie Cheung

May 14
Karen Mckerrall-0-starKaren Mckerrall-1-starKaren Mckerrall-2-starKaren Mckerrall-3-starKaren Mckerrall-4-star

My experience from start to finish with Dr Anna-Maria was honestly such a pleasure. I’d booked in for a consultation for polynucleotides in my under eyes, I’ve done lots of research but had lots of questions which were all answered without judgement. I was really nervous as I had quite a traumatic experience a few years ago when getting lip filler but Dr Anna Maria was really kind and put me at ease and didn’t push me into going ahead with treatment but I felt safe and happy to go for it! I have to say it wasn’t painful at all, slightly odd uncomfortable feeling but completely bearable. If anyone is considering booking injectable treatments but is scared or nervous I can highly recommend Skin Aesthetics will put you at ease, Thankyou so much for your kindness!

Karen Mckerrall

Karen Mckerrall

2024, November 2
Christiana Tsiolas-0-starChristiana Tsiolas-1-starChristiana Tsiolas-2-starChristiana Tsiolas-3-starChristiana Tsiolas-4-star

A Beautiful First Experience! ✨ I recently had my first aesthetic treatment using polynucleotides, and I honestly couldn’t be more impressed. From start to finish, the experience was incredibly professional, calming, and rewarding. Andrea took time to explain everything in detail, which instantly put me at ease. I felt completely informed and comfortable throughout. The treatment itself was surprisingly gentle, with minimal discomfort, and the aftercare guidance was clear and supportive. Within just a few days, I started to notice a natural lift to my under eye area I feel refreshed, almost like a reset for my skin. It’s amazing how something so minimally invasive can make such a noticeable difference. I’d highly recommend this treatment to anyone looking to boost their skin’s health from within. It’s early days, but I already feel more confident and excited to continue the journey. A fantastic introduction to aesthetics—I’ll definitely be back! 💫

Christiana Tsiolas

Christiana Tsiolas

July 30
Emma-0-starEmma-1-starEmma-2-starEmma-3-starEmma-4-star

This is my second visit to Sian for polynucleotides and I have to say how amazing she is really puts you at ease fully knowledgeable with a wealth of experience and full of advice puts together what you need specifically for your skin concerns tailored to you! Ive experienced good fast results with no bruising. Sians wonderful receptionist Keira is amazing from the first foot inside the door you are welcomed and nothing is too much trouble. Highly recommend for perfect location and services offered. Thank you ladies 🥰

Emma

Emma

June 25
Jag M-0-starJag M-1-starJag M-2-starJag M-3-starJag M-4-star

I had the most beautiful experience having my Polynucleotide and NCTF treatment. From the moment I arrived, the space felt so calming and peaceful, i can see that so much love and care has gone into creating that environment. Sofia was incredibly gentle with every step of the treatment, constantly checking in and making sure I felt comfortable. Throughout the entire appointment, Sofia was so nurturing, thoughtful, and completely personal. She has a really soft energy and was genuinely lovely to talk to throughout, which made me feel relaxed and safe in her hands. I can tell she truly cares about both the results and your overall well-being, which is so rare to find. I’m honestly so grateful to have found her and would recommend her to absolutely anyone ♥️

Jag M

Jag M

September 13
About Polynucleotides

About Polynucleotides

If you're looking for Polynucleotides, MARBL makes it easy to compare medical-led clinics in one place. You can compare 261+ clinics for Polynucleotides side by side. Prices typically range from around £80 to £950, depending on the clinic, treatment area and number of sessions. All clinics on MARBL are medical-led and carefully vetted – we list only around 10% of clinics in the UK that meet our safety and quality standards. Browse verified reviews and book your appointment online in just a few clicks.

Polynucleotides uses DNA-derived molecules to promote cellular repair, enhance hydration, and stimulate natural skin regeneration. This cutting-edge treatment activates natural healing processes at a cellular level to address aging, damage, and overall skin quality. The bio-regenerative therapy offers both immediate and progressive benefits through enhanced tissue repair and regeneration.

On MARBL, every clinic offering polynucleotides is vetted for treatment expertise, comprehensive safety protocols, and quality care standards. Treatments are performed by trained specialists with expertise in advanced aesthetic procedures. Each clinic listing includes transparent pricing, detailed procedure information, and guidance on achieving optimal results through professional care.

Polynucleotide sessions typically take 30-45 minutes per treatment, with initial improvements visible within 2-3 weeks and significant tissue regeneration apparent after completing 3-4 session series. You can compare certified specialists near you, check real-time availability, view verified reviews, and book polynucleotides sessions directly through MARBL — achieving your aesthetic goals has never been more convenient.

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FAQs

Polynucleotides are injectable treatments made from purified chains of DNA molecules, typically derived from salmon or trout sperm. These biostimulators work at a cellular level to promote skin regeneration, repair and rejuvenation. When injected into the skin, polynucleotides help to stimulate fibroblast activity, which in turn boosts the production of collagen and elastin, improves hydration and supports natural healing processes. The treatment is designed to improve overall skin quality, texture and tone rather than add volume or change facial structure. Polynucleotides are particularly popular for addressing concerns like crepey skin, fine lines, dullness, under-eye hollows, acne scarring and general signs of ageing.

Prices for Polynucleotides vary between clinics and depend on a number of factors. In the UK, the price of Polynucleotides typically ranges from around £250 to £800. Cost drivers include the specific product used, whether you book a single session or a course of treatments, the practitioner’s experience and the treatment area and goals. Considering the cost of Polynucleotides overall and how much Polynucleotides costs can help you balance price with expected results and practitioner skill. You can find the exact, up-to-date price for this treatment in the catalogue

A polynucleotide treatment involves a series of small injections delivered into the skin using a fine needle or cannula. During your appointment, the practitioner will cleanse the treatment area and may apply numbing cream for comfort. The polynucleotide solution is then injected at multiple points across the target area, such as the face, under-eyes, neck or hands. You may experience mild stinging or pressure during the procedure, and some small bumps or redness immediately afterwards, which typically settle within a few hours to a day. The treatment works gradually by stimulating your skin's natural regeneration processes rather than providing instant volume, so results develop over several weeks as collagen production increases and skin quality improves. Most practitioners recommend a course of treatments spaced a few weeks apart for optimal results.

Polynucleotides have shown promising results in clinical studies and real-world use, particularly for improving skin quality, hydration, elasticity and texture. They work by stimulating the body's natural repair mechanisms rather than simply filling or plumping the skin, which means results tend to look natural and develop gradually. Many people report improvements in skin tone, reduced appearance of fine lines, better hydration and a more refreshed overall appearance. However, effectiveness varies depending on individual factors such as age, skin condition, lifestyle and the severity of concerns being treated. Polynucleotides work best for people looking to improve skin quality and slow down visible signs of ageing, but they are not suitable for dramatic lifting, significant volume loss or deep wrinkles, where other treatments may be more appropriate. A consultation with an experienced practitioner can help determine if polynucleotides are right for your specific concerns.

Polynucleotides work gradually, as they stimulate your skin's natural regeneration processes rather than providing immediate visible changes. Most people begin to notice subtle improvements in skin hydration, texture and radiance within 2 to 4 weeks after their first treatment. More significant results, such as improved elasticity, reduced fine lines and overall skin quality, typically become apparent after completing a full course of treatments, usually over 6 to 8 weeks. The timeline can vary depending on your age, skin condition, the area being treated and how your body responds to the treatment. Because results develop progressively, patience is important, and it can take up to 3 months to see the full benefits. Your practitioner will be able to give you a more personalised timeline based on your individual treatment plan.

The results from polynucleotide treatments typically last between 6 to 12 months, though this varies from person to person. Because polynucleotides work by stimulating your body's natural collagen and elastin production rather than simply adding temporary volume, the improvements can have a longer-lasting effect compared to some other treatments. Factors that influence how long results last include your age, skin quality, lifestyle, sun exposure, skincare routine and whether you have maintenance treatments. Most practitioners recommend an initial course of 2 to 3 sessions spaced a few weeks apart, followed by maintenance treatments once or twice a year to sustain the improvements. The regenerative effects can continue to develop even after the treatment course is complete, as your skin's natural repair processes remain active.

Polynucleotides are generally considered safe when administered by a qualified and experienced practitioner in a clinical setting. The treatment has been used in aesthetic medicine for several years and has a good safety profile. Because polynucleotides are biocompatible and similar to naturally occurring molecules in the human body, the risk of allergic reactions is low. However, as with any injectable treatment, there are potential side effects such as temporary redness, swelling, bruising, tenderness or small bumps at injection sites, which typically resolve within a few days. Rare complications can include infection, prolonged swelling or uneven results. It is essential to choose a reputable, trained practitioner who follows proper hygiene and injection techniques. Always disclose your full medical history, any allergies, medications or existing health conditions during your consultation to ensure the treatment is appropriate for you.

Before polynucleotide treatment, people often have concerns such as dull or tired-looking skin, fine lines, crepey texture, loss of elasticity, uneven skin tone, under-eye hollows or early signs of ageing. After completing a course of polynucleotide treatments, the skin typically appears more hydrated, smoother, firmer and more radiant, with a noticeable improvement in overall skin quality and texture. Fine lines may appear softer, and the skin often has a healthier, more youthful glow. Because polynucleotides work gradually by stimulating natural regeneration, the changes tend to look subtle and natural rather than dramatically altered. Results continue to develop over several weeks and months as collagen production increases. The extent of improvement varies based on individual factors such as age, starting skin condition and lifestyle. Your practitioner can provide realistic before and after examples from their own work to help set appropriate expectations for your specific concerns and goals.